We are getting ready for Week 2 of the NFL and the first game of the week will be in the new home of the Buffalo Bills, Highmark Stadium. This will be the first regular-season game at the new home of the Buffalo Bills. Here is what you need to know.

Buffalo Bills vs Detroit Lions History

Heading into Thursday's game, the Buffalo Bills and Detroit Lions have played each other a total of 13 games. The Bills have won eight times while the Lions have won four times. The two teams played to a 21-21 tie in their first meeting in 1972.

Since 2010, the Buffalo Bills have won 5 straight games, including a high-scoring 48-42 win in Detroit in 2024.

In their 13 games, the Bills have a slight edge when it comes to scoring points. The Bills have scored a total of 274 points in those games, while the Lions have scored a total of 273 points in those games.

READ MORE: CHECK OUT THE BUFFALO BILLS GAME BY GAME PREDICTIONS FOR THE 2026 SEASON 

Thursday's game will be the first time these two teams have played in Buffalo since 2018. The Bills won that game at the old Highmark Stadium 14-13. Josh Allen threw for just over 200 yards and one touchdown. Keith Ford led the Bills in rushing yards with 46 yards.

Both the Bills and the Lions won thier Week 1 games to start this season. The Bills beat Houston on the road 36-31 while the Lions won in overtime against the New Orleans Saints 31-30 at home.

Buffalo Bills Gameday Predictions

I have the Bills winning this game 28-17. They will want to open up the season and the new stadium with a win. Who do you think will win? Let me know HERE or send me a message using our free app.

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Bills Beat Texans Big Week One Defeat, Winning 36-31

The Buffalo Bills did something in Week 1 of the 2026/27 season that they have not done in two decades: they beat the Texans in Houston.

Gallery Credit: Ed Nice

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